Officers from Southern Metro Region arrested two people, including a Mornington man, and seized drugs and a handgun in Seaford last night as part of Operation Night Eagle.
Police were patrolling when they spotted a vehicle of interest at a car wash near the intersection of Klauer Street and Frankston-Dandenong Road about 11pm.
Investigators searched the vehicle and located a high-powered handgun, large quantity of cash and a commercial quantity of drugs.
The pair were both arrested and taken back to a police station where they were interviewed.
A 30-year-old man from Mornington and a 33-year-old woman from Sandhurst have been charged with traffick a commercial quantity of amphetamines, prohibited person possess a firearm and negligently deal with the proceeds of crime.
They are currently in custody assisting police with enquiries.